XU, Shu-xian (徐淑娴)

Currently seeking a Postdoctoral Researcher, Scientist, or other scientific position.

Contact Info

 Citation (Update: June-25-2024)

shuxianxu@outlook.com

ORCID: 0000-0003-3769-2525

Google Scholar: Shuxian Xu

Research Gate: Shuxian Xu

RESEARCH AREAS

  • Integrated clinical and pre-clinical research: neuroinflammation, insulin resistance, and depression via brain-derived extracellular vesicles (EVs).

  • Roles of EVs in mediating brain communication and plasticity.

  • Connection between cognition and neurogenesis in electroconvulsive therapy (ECT).

SKILLS

  • Design and conduct pre- and clinical studies.

  • Single cell / cell culture samples.

  • EV isolation, validation, and downstreams using plasma / cell culture / urine samples.

  • Analyze data utilizing various statistical tools.

EDUCATION

Wuhan University, Wuhan, China (2020 - 2024)

  • Ph.D. candidate in Psychiatry.

  • Main research contents:

    Investigating the status of neuroinflammation, insulin resistance and neurogenesis in patients with major depressive disorder (MDD) using plasma/serum astrocyte-derived extracellular vesicles (ADEVs) and neuro-derived EVs (NDEVs), and the changes before and after ECT.

McGill University, Montreal, Canada (2023 - 2024)

  • Graduate Research Trainee.

  • Main research contents:

    Extracellular vesicle mediation of brain communication and plasticity.

Anhui Medical University, Hefei, China (2014 - 2017)

  • M.S. in Psychiatry.

  • Main research contents:

    New strategy for electroconvulsive therapy (ECT) in mental health patients: maintain efficacy while minimizing side effects.

Southern Medical University, Guangzhou, China (2009 - 2014)

  • M.D. equivalent

PROFESSIONAL EXPERIENCE

Department of Psychiatry, Huizhou Mental Health Center (Second People’s Hospital of Huizhou)

  • Resident Psychiatrist, Residency training program.

Service as Reviewer

  • Frontiers in Psychiatry.
  • BMC Psychiatry.
  • BMC Cardiovascular Disorders.

Publications

(Note: #First author, *Corresponding author, the selected publications were marked in bold)

  1. Wang, C.#, Li, N.#, Feng, Y., Sun, S., Rong, J., Xie, X. H., Xu, S. X. & Liu, Z.* (2024). Effects of autotaxin and lysophosphatidic acid deficiencies on depression-like behaviors in mice exposed to chronic unpredictable mild stress. Neurobiology of Stress, 30, 100632.DOI
  2. Zhang, H.#, Xie, X. H., Xu, S. X., Wang, C., Sun, S., Song, X., Li, R., Li, N., Feng, Y., Duan, H., Li, D., & Liu, Z.* (2024). Oligodendrocyte-derived exosomes-containing SIRT2 ameliorates depressive-like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK-3β pathway in depressed mice. CNS neuroscience & therapeutics, 30(3), e14661.DOI PMID
  3. Xie, X. H.#*, Chen, M. M.#, Xu, S. X., Mei, J. Yang, Q., Wang, C. & Liu, Z.* (2024). Urinary Astrocyte-derived Extracellular Vesicles: A Non-invasive Tool for Capturing Human In Vivo Molecular “Movies” of Brain. medRxiv, 2024.01.12.24301104. DOI
  4. Rong, J.#, Sun, S., Xu, S. X., Xie, X. H., Wang, C., Chen, G., Kang, L., Xiang, D., & Liu, Z.* (2024). The Neuroprotective Effects of BMSC-Derived Exosomes against Glutamate-Induced HT22 Cell Cytotoxicity. Neuroscience, S0306-4522(24)00039-3. DOI PMID
  5. Xie, X. H.#, Xu, S. X.#, Yao, L., Chen, M. M., Zhang, H., Wang, C.,Nagy, C., & Liu, Z.* (2023). Altered In Vivo Early Neurogenesis Traits in Patients with Depression: Evidence from Neuron-Derived Extracellular Vesicles and Electroconvulsive Therapy. Brain stimulation, 17(1), 19–28. DOI PMID
  6. Ma, S.#, Xie, X. H., Deng, Z., Wang, W., Xiang, D., Yao, L., Kang, L., Xu, S. X., Wang, H., Wang, G., Yang, J.*, & Liu, Z.* (2023). A machine learning analysis of “big” metabolomics data for classifying depression: model development and validation. Biological psychiatry, S0006-3223(23)01792-4. Advance online publication. DOI PMID
  7. Huang, T. Y.#, Chen, L. C.#, Li, X. P.#, Li, W. H., Xu, S. X., Nagy, C., Ibrahim, P., Nie, Z. W., Yang, N. Y., Zeng, L., Huang, H. W., Turecki, G., Xie, X. H.* (2023). Elevated Triglycerides and Low Triiodothyronine: Key Risk Factors for Coronary Artery Calcification in Schizophrenia Patients. Schizophrenia research, 264, 113-121. PMID DOI
  8. Zhou, E.#, Wang, W., Ma, S., Xie, X. H., Kang, L., Xu, S. X., Deng, Z., Gong, Q., Nie, Z., Yao, L., Bu, L.*, Wang, F.*, & Liu, Z.* (2023). Prediction of anxious depression using multimodal neuroimaging and machine learning. NeuroImage, 285, 120499. DOI PMID
  9. Yao, L.#, Chen, M., Zhang, N., Ma, S., Xie, X. H., Xu, S., Nie, Z., Wang, W., Zhou, E., Xu, S. X., Weng, S., Chen, H., Xiang, D., & Liu, Z.* (2023). The Mediation Role of Sleep Disturbances between Vitamin D and Depressive Symptoms: A Cross-Sectional Study. Brain sciences, 13(11), 1501. DOI PMID
  10. Xie, X. H.#*, Xu,S. X., Yao, L.H., Chen, M.M. Liu, Z. (2023). ORAL: NEUROGENESIS HYPOTHESIS OF DEPRESSION AND ELECTROCONVULSIVE THERAPY (ECT): HUMAN IN VIVO EVIDENCE FROM PLASMA NEURON-DERIVED EXTRACELLULAR VESICLES (NDEVS). The 23rd WPA World Congress of Psychiatry Vienna, Austria
  11. Xu, S. X.#, Xie, X. H.#, Yao, L., Wang, W., Zhang, H., Chen, M. M., Sun, S., Nie, Z. W., Nagy, C., & Liu, Z.* (2023). Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment-resistant depression following electroconvulsive therapy. Psychiatry and clinical neurosciences, 77, 653–664. DOI PMID
  12. Xu, S. X.#, Xie, X. H.#, Yao, L., Wang, W., Zhang, H., Chen, M. M., … & Liu, Z*. (2023). Trajectories of Efficacy and Cognitive Function During Electroconvulsive Therapy Course in Young Adults with Treatment-Resistant Depression. Neuropsychiatric disease and treatment, 19, 267–281. DOI PMID
  13. Chen, M. M.#, Wang, P., Xie, X. H., Nie, Z., Xu, S. X., Zhang, N., Wang, W., Yao, L., & Liu, Z.* (2023). Young Adults with Major Depression Show Altered Microbiome. Neuroscience, 522, 23–32. DOI PMID
  14. Chen, G.#, Ma, S.#, Gong, Q.#, Xie, X. H., Wu, P., Guo, W., Kang, L., Li, M., Zhang, H., Zhou, E., Zhang, Y., Rong, J., Duan, H., Jin, L., Xu, S. X., Zhang, N., Sun, S., Li, R., Yao, L., Xiang, D., … Liu, Z.* (2023). Assessment of brain imaging and cognitive function in a modified rhesus monkey model of depression. Behavioural brain research, 445, 114382. DOI PMID
  15. Ma, S.#, Wang, W., Gong, Q., Xiang, D., Yao, L., Xu, S. X., Xie, X. H., Wang, H., Wang, G., Yang, J., & Liu, Z.* (2023). Inflammatory bowel disease and the long-term risk of depression: A prospective cohort study of the UK biobank. General hospital psychiatry, 82, 26–32. DOI PMID
  16. Nie, Z., Xie, X. H., Kang, L., Wang, W., Xu, S. X., Chen, M., Yao, L., Gong, Q., Zhou, E., Li, M., Wang, H., Bu, L., & Liu, Z.* (2023). A Cross-Sectional Study: Structural and Related Functional Connectivity Changes in the Brain: Stigmata of Adverse Parenting in Patients with Major Depressive Disorder? Brain sciences, 13(4), 694. DOI PMID
  17. Xie, X. H.#, Lai, W. T., Xu, S. X., Forti, M. D., Zhang, J. Y., Chen, M. M., Yao, L. H., Wang, P. L., Hao, K. K., & Han, R.* (2023). Hyper-inflammation of Astrocytes in Patients of Major Depressive Disorder: Evidence from Serum Astrocyte-derived Extracellular Vesicles. Brain, behavior, and immunity, 109, 51–62. DOI PMID
  18. Yao, L.#, Zhang, N., Ma, S., Xie, X. H., Xu, S. X., Xiang, D., Kang, L., Chen, M. M., Wang, P., & Liu, Z.* (2022). The relationship between vitamin D levels in seasonal variations and Chinese patients with first-episode drug-naive depression. Journal of psychosomatic research, 164, 111079. DOI PMID
  19. Xu, S. X.#, Xie, X. H., Su, D., & Liu, Z.* (2022). Electroconvulsive Therapy in a Young Adult Patient With Bipolar Depression and Dysembryoplastic Neuroepithelial Tumor: A Case Report. The journal of ECT, 10.1097/YCT.0000000000000876. DOI PMID
  20. Zhang, J. Y.#, Xu, S. X.#, Zeng, L.#, Chen, L. C., Li, J., Jiang, Z. Y., Tan, B. J., Gu, C. L., Lai, W. T., Kong, X. M., Wang, J., Rong, H., & Xie, X. H.* (2022). Improved Safety of Hybrid Electroconvulsive Therapy Compared With Standard Electroconvulsive Therapy in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Parallel-Group Pilot Trial. Frontiers in psychiatry, 13, 896018. DOI PMID
  21. Xu, S. X.#, Deng, W. F.#, Qu, Y. Y.#, Lai, W. T., Huang, T. Y., Rong, H., & Xie, X. H.* (2021). The integrated understanding of structural and functional connectomes in depression: A multimodal meta-analysis of graph metrics. Journal of affective disorders, 295, 759–770. DOI PMID
  22. Huang, T. Y.#, Deng, W. F.#, Li, X. P., Chen, H. Q., Xu, S. X., Ke, S. H., & Xie, X. H.* (2021). Higher prevalence of coronary artery calcification in schizophrenia patients. Schizophrenia research, 231, 47–48. DOI PMID
  23. Li, J.#, Deng, W. F.#, Xu, S. X.#, Jiang, Z. Y., Rong, H., Kong, X. M., & Xie, X. H.* (2021). The efficacy and acceptability of hybrid electroconvulsive therapy compared with standard electroconvulsive therapy for schizophrenia patients: A parallel-group, double-blind, randomized, controlled trial. Brain stimulation, 14(3), 737–739. DOI PMID
  24. Lai, W. T.#, Zhao, J.#, Xu, S. X.#, Deng, W. F.#, Xu, D., Wang, M. B., He, F. S., Liu, Y. H., Guo, Y. Y., Ye, S. W., Yang, Q. F., Zhang, Y. L., Wang, S., Li, M. Z., Yang, Y. J., Liu, T. B., Tan, Z. M., Xie, X. H.*, & Rong, H.* (2021). Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in bipolar disorder with current major depressive episode patients. Journal of affective disorders, 278, 311–319. DOI PMID
  25. Lai, W. T.#, Deng, W. F.#, Xu, S. X.#, Zhao, J., Xu, D., Liu, Y. H., Guo, Y. Y., Wang, M. B., He, F. S., Ye, S. W., Yang, Q. F., Liu, T. B., Zhang, Y. L., Wang, S., Li, M. Z., Yang, Y. J., Xie, X. H.*, & Rong, H.* (2021). Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients. Psychological medicine, 51(1), 90–101. DOI PMID
  26. Rong, H.#, Xu, S. X.#, Zeng, J.#, Yang, Y. J., Zhao, J., Lai, W. T., Chen, L. C., Deng, W. F., Zhang, X., Zhang, Y. L., Li, M. Z., Xiao, L., & Xie, X. H.* (2019). Study protocol for a parallel-group, double-blinded, randomized, controlled, noninferiority trial: the effect and safety of hybrid electroconvulsive therapy (Hybrid-ECT) compared with routine electroconvulsive therapy in patients with depression. BMC psychiatry, 19(1), 344. DOI PMID
  27. Kong, X. M.#, Xie, X. H., Xu, S. X., Chen, Y., Wang, C., Hong, H., & Sun, Y.* (2019). Low-Charge Electrotherapy in Geriatric Major Depressive Disorder Patients: A Case Series. Psychiatry investigation, 16(6), 464–468. DOI PMID
  28. Rong, H.#, Xie, X. H.#, Zhao, J., Lai, W. T., Wang, M. B., Xu, D., Liu, Y. H., Guo, Y. Y., Xu, S. X., Deng, W. F., Yang, Q. F., Xiao, L., Zhang, Y. L., He, F. S., Wang, S., & Liu, T. B.* (2019). Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients. Journal of psychiatric research, 113, 90–99. DOI PMID
  29. Li, M. Z.#, Chen, L. C.#, Rong, H., Xu, S. X., Li, Y., Yang, Q. F., Deng, W. F., Yang, H. Z., Kong, X. M., Xiao, L., & Xie, X. H.* (2019). Low-charge electrotherapy for patients with schizophrenia: A double-blind, randomised controlled pilot clinical trial. Psychiatry research, 272, 676–681. DOI PMID
  30. Kong, X. M.#, Xu, S. X.#, Sun, Y., Wang, K. Y., Wang, C., Zhang, J., Xia, J. X., Zhang, L., Tan, B. J., & Xie, X. H.* (2017). Electroconvulsive therapy changes the regional resting state function measured by regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in elderly major depressive disorder patients: An exploratory study. Psychiatry research. Neuroimaging, 264, 13–21. DOI PMID
  31. Xu, S. X.#, Huang, Y.#, Xiao, J., Zhu, W., Wang, L., Tang, H., … & Liu, T*. The association between job strain and coronary heart disease: a meta-analysis of prospective cohort studies. Annals of medicine, 47(6), 512–518. DOI PMID
  32. Huang, Y. #, Xu, S. X. #, Hua, J., Zhu, D., Liu, C., Hu, Y., … & Xu, D*. Association between job strain and risk of incident stroke: A meta-analysis. Neurology, 85(19), 1648–1654. DOI PMID